A liquid phospholipid formulation of a Curcumin extract with high concentration of phosphatidylcholine improves the transport of Curcuminoids across Caco-2 intestinal epithelial cells

Gebhardt, P., Van Hoogevest, P., Engelhart-Jentzsch, K., Agro Food Industry Hi-Tech, 30(4), 56-59 (2019)

The use of curcumin as dietary supplement to ameliorate inflammation, arthritis, stomach, skin, liver, and gallbladder problems, is hampered by the lack of oral absorption. In this study, an in vitro digestion method and Caco-2 cell-lines were used to assess the influence of the solubilisation of curcuminoids in a liquid formulation comprising a high content of phosphatidylcholine on the transport of the curcuminoids across a Caco-2 cell monolayer, compared to powdered curcuminoids. A LC-MS method was used to assess the content of the curcuminoids after digestion and in the basolateral compartment of the Caco-2 model. It was found that the solubilization in the phospholipid concentrate significantly increases curcuminoids transport across the Caco-2 cells.